Mouse studies of SARS coronavirus-specific immune responses to recombinant replication-defective adenovirus expressing SARS coronavirus N protein.
Identifieur interne : 002A71 ( Main/Exploration ); précédent : 002A70; suivant : 002A72Mouse studies of SARS coronavirus-specific immune responses to recombinant replication-defective adenovirus expressing SARS coronavirus N protein.
Auteurs : F W Y. Sin [République populaire de Chine] ; S C S. Cheng ; K T Chan ; L. Meng ; J. Yu ; Y. XieSource :
- Hong Kong medical journal = Xianggang yi xue za zhi [ 1024-2708 ] ; 2009.
Descripteurs français
- KwdFr :
- Adenoviridae (génétique), Animaux, Antigène HLA-A2 (génétique), Femelle, Humains, Production d'anticorps, Protéines nucléocapside (génétique), Protéines nucléocapside (immunologie), Souris, Souris de lignée BALB C, Souris transgéniques, Vaccins antiviraux (immunologie), Vecteurs génétiques, Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
English descriptors
- KwdEn :
- Adenoviridae (genetics), Animals, Antibody Formation, Female, Genetic Vectors, HLA-A2 Antigen (genetics), Humans, Mice, Mice, Inbred BALB C, Mice, Transgenic, Nucleocapsid Proteins (genetics), Nucleocapsid Proteins (immunology), SARS Virus (genetics), SARS Virus (immunology), Viral Vaccines (immunology).
- MESH :
- chemical , genetics : HLA-A2 Antigen, Nucleocapsid Proteins.
- genetics : Adenoviridae, SARS Virus.
- chemical , immunology : Nucleocapsid Proteins, SARS Virus, Viral Vaccines.
- Animals, Antibody Formation, Female, Genetic Vectors, Humans, Mice, Mice, Inbred BALB C, Mice, Transgenic.
Abstract
1. A recombinant adenovirus encoding SARS coronavirus(SARS-CoV) nucleocapsid protein (rAd-N) was constructed. 2. The ability of the rAd-N to induce anti-SARS-CoV N antibody production and cellular immune responses was evaluated in an HLA-A2.1/Kb transgenic mouse model.
PubMed: 19258632
Affiliations:
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Le document en format XML
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Cheng</name></author><author><name sortKey="Chan, K T" sort="Chan, K T" uniqKey="Chan K" first="K T" last="Chan">K T Chan</name></author><author><name sortKey="Meng, L" sort="Meng, L" uniqKey="Meng L" first="L" last="Meng">L. Meng</name></author><author><name sortKey="Yu, J" sort="Yu, J" uniqKey="Yu J" first="J" last="Yu">J. Yu</name></author><author><name sortKey="Xie, Y" sort="Xie, Y" uniqKey="Xie Y" first="Y" last="Xie">Y. 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Sin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, S C S" sort="Cheng, S C S" uniqKey="Cheng S" first="S C S" last="Cheng">S C S. Cheng</name></author><author><name sortKey="Chan, K T" sort="Chan, K T" uniqKey="Chan K" first="K T" last="Chan">K T Chan</name></author><author><name sortKey="Meng, L" sort="Meng, L" uniqKey="Meng L" first="L" last="Meng">L. Meng</name></author><author><name sortKey="Yu, J" sort="Yu, J" uniqKey="Yu J" first="J" last="Yu">J. Yu</name></author><author><name sortKey="Xie, Y" sort="Xie, Y" uniqKey="Xie Y" first="Y" last="Xie">Y. Xie</name></author></analytic><series><title level="j">Hong Kong medical journal = Xianggang yi xue za zhi</title><idno type="ISSN">1024-2708</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae (genetics)</term><term>Animals</term><term>Antibody Formation</term><term>Female</term><term>Genetic Vectors</term><term>HLA-A2 Antigen (genetics)</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Transgenic</term><term>Nucleocapsid Proteins (genetics)</term><term>Nucleocapsid Proteins (immunology)</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (génétique)</term><term>Animaux</term><term>Antigène HLA-A2 (génétique)</term><term>Femelle</term><term>Humains</term><term>Production d'anticorps</term><term>Protéines nucléocapside (génétique)</term><term>Protéines nucléocapside (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris transgéniques</term><term>Vaccins antiviraux (immunologie)</term><term>Vecteurs génétiques</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA-A2 Antigen</term><term>Nucleocapsid Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenoviridae</term><term>Antigène HLA-A2</term><term>Protéines nucléocapside</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Protéines nucléocapside</term><term>Vaccins antiviraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Nucleocapsid Proteins</term><term>SARS Virus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibody Formation</term><term>Female</term><term>Genetic Vectors</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Transgenic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Production d'anticorps</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris transgéniques</term><term>Vecteurs génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. A recombinant adenovirus encoding SARS coronavirus(SARS-CoV) nucleocapsid protein (rAd-N) was constructed. 2. The ability of the rAd-N to induce anti-SARS-CoV N antibody production and cellular immune responses was evaluated in an HLA-A2.1/Kb transgenic mouse model.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chan, K T" sort="Chan, K T" uniqKey="Chan K" first="K T" last="Chan">K T Chan</name><name sortKey="Cheng, S C S" sort="Cheng, S C S" uniqKey="Cheng S" first="S C S" last="Cheng">S C S. Cheng</name><name sortKey="Meng, L" sort="Meng, L" uniqKey="Meng L" first="L" last="Meng">L. Meng</name><name sortKey="Xie, Y" sort="Xie, Y" uniqKey="Xie Y" first="Y" last="Xie">Y. Xie</name><name sortKey="Yu, J" sort="Yu, J" uniqKey="Yu J" first="J" last="Yu">J. Yu</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Sin, F W Y" sort="Sin, F W Y" uniqKey="Sin F" first="F W Y" last="Sin">F W Y. Sin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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